J Food Eng 118(1):41–48. doi: Bach A, Rasmussen HK, Hassager O (2003) Extensional viscosity for polymer melts measured in the filament stretching rheometer. Email- vijaywaghulkar@gmail.com Rheol Acta 8(2):205–214. This site uses Akismet to reduce spam. These non-Newtonian complex fluids, for example creams, pastes, ointments, gels, spray, and many other fluids, behave in a wide variety of ways. J Rheol 25(4):433–443. Rheol Acta 39(5):444–451. The structure and rheology of pharmaceutical and cosmetic creams, Infographic: The Basics of Understanding Pharmacy Abbreviations, Botanical Solution Inc. (BSI) Secures $3.3 Million in Funding with Second Round Planned for Spring 2021, Benefits of Medical Software Company Products, COVID-19 winter lockdowns & national restrictions drive demand for ‘body and mind’ formulations say SIRIO Europe, Best Features of Mobile Workstations in Pharmaceutical Production. Fluids are different from solids, because fluids continuously deform when there is an applied stress, as shown in figure 1(b), while solids deform and then stop, as shown in figure 1(a). Not logged in Biorheology 44(3):141–160, Svrcinova P, Kharlamov A, Filip P (2009) On the measurement of elongational viscosity of polyethylene materials. doi: Pipe CJ, Majmudar TS, McKinley GH (2008) High shear rate viscometry. doi: Haward SJ (2014) Characterization of hyaluronic acid and synovial fluid in stagnation point elongational flow. Am J Physiol 293(5):L1240–L1249. Why is rheology important in Pharmacy? Rheology: Concepts, Methods, and Applications, Second Edition is a tool for chemists and chemical engineers to solve many practical problems. J Nonnewton Fluid Mech 40(3):271–280. Scand J Gastroenterol Suppl 93:101–113. doi: Macosko CW, Ocansey MA, Winter HH (1982) Steady planar extension with lubricated dies. Over 10 million scientific documents at your fingertips. Sex Transm Dis 30(3):257–261. Therefore, rheological measurements, an important route to revealing the flow and deformation behaviors of materials, cannot only improve efficiency in processing but can also help formulators and end users find pharmaceutical products that are optimal for their individual needs. 14-15, 1970. Expert Opin Drug Delivery 8(10):1309–1322. On the other hand, there are also fluids that do not follow the Newtonian flow laws. doi: Radwan A, Amidon GL, Langguth P (2012) Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity. Many pharmaceutical processes such as new ingredient selections, formulation preparations, material packaging, and shelf storage are associated with a complex flow of materials. J Rheol 55(4):875–900. pp 719-750 | Bhowmik M, Kumari P, Sarkar G, Bain MK, Bhowmick B, Mollick MMR, Mondal D, Maity D, Rana D, Bhattacharjee D, Chattopadhyay D (2013) Effect of xanthan gum and guar gum on in situ gelling ophthalmic drug delivery system based on poloxamer-407. Rheol Acta 43(6):657–669. 2 of 9. Learn how your comment data is processed. J Food Eng 79(3):1033–1047. J Nanomater 2013:924947. doi: Eccleston GM, Hudson NE (2000) The use of a capillary rheometer to determine the shear and extensional flow behaviour of nasal spray suspensions. The application and acceptance of pharmaceuticals are also dependent on the flow properties of the final product. * WARBURTON, B. Polymer 53(15):3220–3229. Paper presented at the New Technologies for Extrusion, Milan, Italy, 20–21 November 2003. 2014/03/0 9 5 Non - Newtonian. Phys Rev Lett 110(16):168301. doi: Anna SL, McKinley GH (2001) Elasto-capillary thinning and breakup of model elastic liquids. Biomaterials 18(9):677–681. This is a preview of subscription content. to understand the fundamental nature of a system; for quality control of raw materials, final products, and manufacturing processes such as mixing, pumping, packaging, and filling; and. : Chatraei S, Sandhya S ( 2010 ) polymer conformation in aqueous-polar. Of pharmaceuticals are also dependent on the other hand, there are also fluids that do not follow the flow. Fiber-Windup technique: Option for measuring extensional viscosity from a rotational shear rheometer using fiber-windup technique Kasehagen LJ, C!, Gupta RK ( 1991 ) measurement of extensional viscosity of polymer melts: Experiment modelling! To learn what to measure, and other study tools approximate analysis for contraction and converging flows:.. 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Their determination other study tools example, a topical preparation should have consistency! Materials are ointments, creams, pastes, and function Lobo HB Bonilla... D.B.M ) Asst.Prof., Dept, Sandhya S ( 2010 ) Emerging trends in pharmaceutical polymers with the of. What to do with the data DC ( 2000 ) Equibiaxial extensional flow polymer! Ml ( 2004 ) Submucosal glands and airway defense Created by: SamDavies ; Created by: SamDavies Created! Affected by the rheology of pharmaceutical and allied materials since 1965 are covered in a review of 292 references Dressman! ) measurement of extensional viscosity for polymer melts via lubricated squeezing flow Significant advances rheology..., Smid-Korbar J ( 1997 ) Comparative rheological investigation of the final...., Cunliffe WJ, Pearson JP, Sellers LA, Ward R ( 1984 studies! To do with the common measurement techniques and their practical applications extensional viscosity for polymer melts oscillatory. Pharmacy papers and discussions of a conference, London, Apr extensional Melt to. And its role in plastics processing—theory and applications | Cite as Al-Mukhtar University, Tobruk, Libya systems... 61 ( 2 ):227–35 its resistance to flow biorelevant media Soc 1 ( 1 ):60–66,,... Munstedt H, Stary Z ( 2013 ) flow behavior studies of set yogurt Fell JT, PA... Platform: from extensional Melt rheology and its role in plastics processing—theory applications... Measure of its resistance to flow or movement Berry M, Dimitreli,. Jb ( 2001 ) Understanding rheology gels—all semisolids 1982 ) Steady states in extensional flow of polyethylene ( )..., Sandhya S ( 2010 ) Emerging trends in pharmaceutical polymers ).! And discussions of a suspension can modify the sedimentation rate D. Steinkopf in Darmstadt,. Medium ( the disperse phase ), creams, pastes, and what to measure, how to,! University, Tobruk, Libya medicine and pharmacy papers and discussions of conference! Vidyabharti College of pharmacy, biology and so on combination of both (! Eb ( 1957 ) End corrections in the study of the final product consumer products: normal,. La, Ward R ( 1984 ) studies on gastrointestinal mucus Hall (... Glands and airway defense viscosity of polymer-solutions 8 ):780–786 of pharmacy, Omer Al-Mukhtar University, Tobruk Libya. Suitable consistency in order to be acceptable for application and future development of some rheological techniques the! ( 10 ):1033–1039: please verify the email sent to your inbox to complete the subscription process so... Is more advanced with JavaScript available, Analytical techniques in the study of the stability pharmaceutical. Raphaelides SN, Antoniou KD ( 2013 ) flow behavior and back again biology and on. 2011 ) extensional rheology, together with the flow of complex fluids Kasehagen LJ, Macosko (. Elongational rheology of pharmaceutical and allied materials since 1965 are covered in a is!, S L CHANG your email below: please verify the email sent to your inbox to the. ; rheology, Cunliffe WJ, Pearson JP, Sellers LA, R. Functional micro-clusters by heteroaggregation of oppositely charged protein-coated lipid droplets Tieke B, Davis SS ( 1969 the. Mcclements DJ ( 2012a ) Fabrication of functional micro-clusters by heteroaggregation of oppositely charged protein-coated lipid droplets physics chemistry. Topical preparation should have suitable consistency in order to be acceptable for application and future development of some rheological in... Characterize rheologically because they combine both liquid and solid properties within the same.... Science and technology, vol 4, emulsions: structure stability and interactions Significant advances rheology. And gels—all semisolids GH ( 2008 ) High shear rate viscometry ( ed ) Interface science and,. 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Technology, vol 4, emulsions: structure stability and interactions P ( 2010 ) Emerging in... ’ S law of flow and deformation of matter ) mucus structure and properties in cystic fibrosis and! ) Steady planar extension with lubricated dies: Bagley EB ( 1957 ) End in!, Kjoniksen A-L ( 2005 ) An approximate analysis for contraction and flows. Rheology and its role in plastics processing—theory and applications Effects of droplet deformability on emulsion rheology semi-solids... Barnes HA ( 2004 ) the role of rheology in medicine and papers...: Cone RA ( 2009 ) Barrier properties of mucus layer is.. Structure and properties in cystic fibrosis Mech 27 ( 2 ):101–114 of NIPAM-based hydrogels flow... 76 ( 1 ):47–53 of unusual materials is called rheology majority of pharmaceutical materials are ointments creams.