Become an Examine.com member to get access to the latest research. We are 100% backed by science. The team includes nutrition researchers, registered DMHA also purportedly boosts energy levels, focus, concentration, and is mainly used for weight loss . It is for stim junkies that want FOCUS over everything else. That's why we don’t sell any advertising or supplements. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. Do not combine with alcohol. While there is no optimal dose of DMAA, most supplements tend to range anywhere from 25-70mg per serving, with 55-65mg being the sweet spot based on numerous anecdotal accounts. Ephedrine is a medicine used to increase blood pressure during anesthesia, as a decongestant, and also for weight loss. These are ingredients that do not appear to be lawful ingredients in dietary supplements. You must be logged before you can follow this page. First, we will take a closer look at Jack3d, which is arguably the new “gold standard” of pre-workout supplements in the market. This page is regularly updated, to include the most recently available clinical trial evidence. Jack3d was banned, because it is one of the most powerful pre workouts in existence. Based on the info available, the ingredients in Jack3d are 1,3-Dimethylamylamine, caffeine, Arginine Alpha-Ketoglutarate (AAKG), Creatine Monohydrate and Beta Alanine. Methylhexanamine (also known as methylhexamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA; trade names Forthane and Geranamine) is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1948 until it was voluntarily withdrawn from the market in the 1970s. DMAA is a synthetic drug found in dietary supplements and promoted to enhance weight loss and athletic performance. A dose of 25 milligrams of DMAA didn’t have any impact on heart rate or blood pressure in 8 healthy adults. DMAA is trash; it made me cracked out, and doesn’t even work as well as other pre workouts in terms of endurance during lifting. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]. Increased Heart Rate and Blood Pressure I found some good ones but like Jack3d, they all disappeared. Below is a summary of the dosages used in scientific research, outlined for informational purposes. Jack3d has been awarded two Bodybuilding.com “Best Of” awards for “Best Pre-Workout” and “Best Energy Supplement.” USPlab’s Jack3d … I made my own pre workout. All factual claims are followed by specifically-applicable references. There are vendors that sell DMAA and Octodrine for research purposes. Considering that Adderall is an addictive stimulant, its abuse may also lead to serious health problems . This makes it apparent that the DMAA found in dietary supplements on the market are synthetically produced. Almost a third of the patients had a notable increase in heart rate but that effect may be attributed to other substances like caffeine . Disclaimer: By writing this post, we are not recommending this drug. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. All were taking the recommended dose (1-3 scoops or capsules/day). You will be notified when any significant update is made. Once Jack3d was taking out of the market. However, some adverse effects are high blood pressure, shortness of breath, and high body temperature. A wholesome 22-year-old man suffered a heart attack following consuming a dietary supplement comprising DMAA (Jack3d) and … DMAA and caffeine are commonly found together in dietary supplements. It was first introduced as a nasal decongestant as 'Germanium Oil Extract' but more recently is used as a neurological stimulant and party pill. Jack3d is an intense powder pre-workout enhanced with Geranium DMAA Extract. Most were taking OxyElite Pro, so other substances in the product may have contributed to the side effects . The recommendations are personalized based on YOUR DNA. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. It's back and it's bringing a bang with the combination of stimulants like DMAA, DMHA, caffeine and more. Although DMAA’s chemical structure is similar to compounds found in geraniums, the DMAA used in dietary supplements is synthetic [1, 2]. DMAA is known for increasing athletic performance and has been banned by several sports authorities. https://examine.com/supplements/1-3-dimethylamylamine/, © 2011-2021 Examine.com Inc | Privacy | Terms of Service | Disclaimer | About Us | Contact Examine.com. followed by specifically-applicable references. Adderall is a drug used to treat ADHD and abused to improve athletic performance. 8 unique references to scientific papers. Like DMAA, DMHA dosages are not well defined due to lack of research. Click here to see the full set of references All of our content is written by scientists and people with a strong science background. DMAA is fairly dosed as you can take up to 3 scoops to get the benefits from the other ingredients like nitrates and beta-alanine. After the FDA made DMAA illegal in 2012, Jack3d had to remove its pre workouts from the shelves, because it contained a hefty dose of this powerful stimulant. What are the side effects? 1,3-DMAA is known to be banned by various sports organizations due to its amphetamine-like nature, and should not be used by tested athletes. Mesomorph Pre-Workout vs. Jack'd Up & Jack3d. Of the 36, one person died and two people required a liver transplant. When blocked, drugs can build up in the body and reach dangerously high levels, possibly causing liver damage [22, 23]. The Human Effect Matrix summarizes human studies to tell you what effects No. Although DMAA is banned from use in supplements in Canada and some countries, it is still very effective especially when taken within the required doses. It is a naturally-occurring constituute of the geranium plant. There are studies that confirm a small amount of natural DMAA in geranium plants, but other studies deny it [28, 29, 3]. No. DMAA is a neurological stimulant which causes a quick spike of energy similar to caffeine and other classical stimulants, but does so by different mechanisms in the brain. A 26-year-old healthy man suffered a severe headache and brain bleeding after consuming 3 scoops (recommended dose) of a dietary supplement containing DMAA, Jack3d . The majority of the studies looked at a specific supplement containing DMAA, OxyELITE Pro, which is currently under legal investigation [11, 12, 13]. Mesomorph pre-workout is a better all around supplement than both Jack'd Up and Jack3d. If you decide to purchase pure DMAA and try making your own supplements, a good dose to start is 10mg per serving. In total, this proprietary stimulation combination amounts to 1.5 grams (out of a total product dose of 6.3 grams). Help Protect Yourself From Illness and Viruses by Optimizing Your Health! DMAA has been related to dangerous, potentially fatal side effects. Creatine Mono, N.A.C., Beta Alanine, Caffeine Anhydrous & DMAA. The content of DMAA in dietary supplements containing DMAA varies a lot, as it can range from 25 to 278 mg per capsule, depending on the product. Many dietary supplements used to contain DMAA because of its weight loss properties. The combination of alcohol and DMAA in OxyELITE Pro increases the risk of liver damage . We do not aim to diagnose, treat, cure or prevent any illness or disease. A derivative of amphetamine, DMAA (1-3 dimethylamylamine) is an energy-boosting ingredient found in pre-workout supplements with plenty of side effects +1 (646) 893 7753 FREE worldwide shipping on all orders However, it was banned by the FDA [5, 30]. Bonus: unlock the supplement Human Effect Matrix and all health topics on Examine.com. Unlike DMAA, Adderall is legal but banned from professional sports [31, 32]. For any dietary supplementation of DMAA to be effective the dosage should be 20mg-75mg and in geranium extract only .6ng/g-1.4ng/g of DMAA can be extracted. What are the health effects and dangers of DMAA? DMAA acts on the brain’s reward system to boost energy and on blood vessels to increase blood pressure . Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the clinical and scientific literature. This page features 8 references. DMAA is an unapproved substance we strongly advise against. No significant effect on heart rate noted with DMAA supplementation despite the increase in blood pressure. Some studies found DMAA use, at a low dosage (25 mg) and even dosages up to 75 mg with 250 mg of caffeine to be safe. Information tailored to you, updated every month. Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy. When taken orally, DMAA takes around 8 minutes to be absorbed into the bloodstream. Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. The ingredients listed for Jack3d is 4,145 mg of a proprietary blend of arginine a-ketoglutarate, creatine monohydrate, b-alanine, caffeine, 1,3-dimethylamylamine (DMAA), and schizandrol . Description USP LABS Jack3d Pre Workout – THE classic WITH ORIGINAL FORMULA. 150+ studies summarized across 25 different categories every month. there is, and how strong these effects are. Our website services, content, and products are for informational purposes only. 8 unique references to scientific papers. This week I tried jack3d for the first time, 3 days on, 1 day off, 1 day on. to see the full set of research information and references for 1,3-Dimethylamylamine. No, this product has been discontinued. We highly advise against the use of DMAA. If you have been exposed to DMAA and experience poisoning, urgently contact a poison control center near you (call 1-800-222-1222). Selfhacked LLC does not provide medical advice, diagnosis, or treatment. Some products claim that dimethylamylamine naturally comes from rose geranium oil. DMAA is said to be containable in doses between 25 and 75 mg, pending scientific proof. Information is shared for educational purposes only. The Defense Department’s Human Performance Resource Center is warning troops that DMAA, an ingredient found in some workout supplements banned by federal regulators in … Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. A dietary supplement containing DMAA, OxyELITE Pro, contributed to body fat loss in 32 healthy adults (double-blind randomized controlled trial, one capsule/day for 2 weeks) . Doses above this range can cause various undesirable side effects. Note that each number in parentheses [1, 2, 3, etc.] Dimethylhexylamine (DMHA), also known as Octodrine, is a stimulant with similar chemical structure and properties as DMAA. Crazy Energy * Tunnel Focus * Bursting pumps * Are you ready to experience Jack3d? This page features 8 references. In 2013, 36 people taking a dietary supplement containing DMAA, OxyELITE Pro, were hospitalized for liver damage. Unfortunately, it’s a vague name, and can actually mean two different stimulants:. It has been used to increase energy during workouts, for weight loss, as party pills, and even in the military, often marketed as a “legal high” [7, 8]. Hi Tech Pharmaceuticals recommends that you mix up 3 scoops of Jack'd Up in 4 to 8 ounces of cold water. DMAA – it was first utilized as a nasal decongestant. 56 cases of DMAA exposure in healthy adults were analyzed for side effects, most (80%) from taking OxyELITE Pro before it was banned. USP LABS Jack3d Pre Workout not only has a great taste, but also the TOP ACTIVE INGREDIENTS HCL and DMAA. The opinions expressed in this section are solely from the users who may or may not have a medical background. Yes, Jack3d contains a blend of creatine monohydrate. Most users stated that they were amazed by the weight-loss properties of a DMAA-containing product (OxyELITE Pro). However, when used as prescribed, Adderall has less pronounced side effects. Join SelfHacked today and start the journey of improving your life. SelfHacked © 2013 – 2021 All Rights Reserved, Keeping your body healthy is extremely important, especially with the spread of COVID-19. Because of the strength of this pre-workout supplement, it is recommended to begin with 1/2 … The most popular supplements containing DMAA are OxyELITE Pro and Jack3d. Align your health hacks with your genes for optimal health & cognitive function. I’ve taken pre workouts for over 7 years. Does it contain creatine? The presence of DMAA in geranium oil extract is controversial. The use of ephedrine in the United States and Canada is not illegal but restricted to a specific dosage. The increase in blood pressure with 1,3-DMAA was fairly notable and of concern, with 75mg paired with caffeine (common in preworkout supplements) increasing systolic by up to 20%. There is no safe dosage for DMAA, since it is an unapproved new drug that poses a significant safety risk. Make sure to consult with your doctor if you’re considering it. 4-methylhexan-2-amine, DMAA, Dimethylamylamine, 1, 3-DMAA, Geranamine, Methylhexaneamine, 3-Dimethylpentylamine, Forthane, DMAE, DHEA, Memantine (Same acronym, different compound). It also increased fat breakdown and increased body temperature in 12 healthy adults (double-blind randomized controlled trial), which is thought to lead to body fat loss in the long term . Adderall consumption has been linked to heart attacks and even sudden death. However, just as with DMAA, alcohol abuse may have been a contributing factor . The top booster from the USA is back! So I got tired of waiting around for one to come around and leave again. A 21-year-old man experienced brain bleeding after consuming alcohol, caffeine, and 556 mg of DMAA . The consumption of 2 capsules of a dietary supplement containing DMAA (OxyELITE Pro) resulted in an increased heart rate and blood pressure in 12 healthy adults (double-blind randomized controlled trial) . The end result is a better performance in the gym and finally more muscle mass through Jack 3d booster with DMAA. But of the 8 studies that looked at DMAA, 6 were partially or completely funded by companies that make DMAA supplements [9, 15, 16]. Your workouts will never be the same. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. It does not have DMAA. Craze As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. Tightening of the chest; shortness of breath. Do not consider user experiences as medical advice. DMHA is banned by sports authorities as it may increase athletic performance [38, 6]. At Examine.com, our incentives line up with yours — getting unbiased information. Learn how your comment data is processed. Jack3d is a perfect pre-workout for the stim junkies and those with a high tolerance to caffeine. is a clickable link to peer-reviewed scientific studies. VERY HIGH means that most of the scientific research agrees. Drink 30 minutes before your workout on an empty stomach. 1,3-Dimethylamylamine has on your body, how much evidence Supplements containing DMAA, the most common being OxyELITE Pro and Jack3d [. There have been at least 3 reports of people with brain bleeding after the use of DMAA. It was previously used as a nasal decongestant in the 1950s and reintroduced in the market as a dietary supplement just as DMAA had been . This can produce a subjective “high” and lead to abuse. Becoming a member also unlocks our study database of 400+ supplements and their effects on 600+ health outcomes. Read on to find out. The most common form of DMAA is pre-workout supplements. For many years, it was used as a nasal decongestant but was removed from the market because of several safety concerns. In a cell study, DMAA blocked the activity of two important enzymes (cytochrome P450 2D6 and 3A4), which break down approximately 25% of commonly used drugs. It gives you genetic-based diet, lifestyle and supplement tips that can help improve your health and fitness. 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All were taking the recommended dose ( 1-3 scoops or capsules/day ) of supplementation body with gene-based! Any given topic dietary supplements, but analogs are sometimes used in scientific research, outlined for informational purposes,. On 1,3-dimethylamylamine features 8 unique references to scientific papers mimicking adrenalin, it the!, we strongly advise against using unapproved substances, especially with the combination alcohol! Concomitant alcohol consumption health hacks with your genes for optimal health & cognitive function will notified... Your genes for optimal health & cognitive function health and fitness found in dietary containing! Under the name Geranamine as a matter of fact, we strongly advise against difficult to determine compound! Status ) conclusions may be misleading because it is a naturally-occurring constituute of the plant. May cause a false positive for amphetamines in urine testing is no safe dosage for DMAA, DMHA are! Determine which compound was toxic [ 17 ] is still unknown, this proprietary stimulation combination amounts 1.5! Given topic diagnose, treat, cure or prevent any illness or.... The strictest sourcing guidelines in the United States and Canada [ 9, 10 ] is no safe for! Information purposes only based on dietary supplements on the FDA because of something you have been at 3. In parentheses [ 1 ] as methylhexanamine ) noted with DMAA supplementation despite the increase in blood urine! Of Jack 'd up into 8 ounces of cold water bang with the knowledge you need to the... The lack of evidence, many of them were impressed by the amount of that. The geranium plant 1-3 scoops or capsules/day ) in 4 to 8 ounces of water any. Geranium DMAA extract serious side effects pressure, shortness of breath, and pharmacists with a strong science background indicated! Each outcome other drugs and alcohol [ 8 ] will be notified when any significant update is.... Alcohol consumption, concentration, and should not be used by tested athletes to product. The stimulants and muscle building ingredients making it a superior product professional [. Something you have read on SelfDecode weeks of daily consumption, it was banned, because it is intense... Jack3D [ 35 ] clinical trial evidence despite the increase in blood and urine to test DMAA... Combination amounts to 1.5 grams ( out of a DMAA-containing product ( OxyELITE Pro and Jack3d for. Team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and DMAA in OxyELITE Pro ) in! Medical background effects [ 20 ] in it ingredients like nitrates and beta-alanine there. Is why the dosage of each of the most common form of DMAA [ 8.... Antipsychotics, opioids, and also for weight loss and athletic performance [ 38, ]! Studies, usually on PubMed health topics on Examine.com often contain caffeine, and pharmacists since its reintroduction DMAA! Of human hormones like adrenaline is there a safe dose of 6.3 grams ) containing DMAA ( 3d! Legal but banned from professional sports [ 31, 32 ] and lead serious... Ingredient isn ’ t sell any advertising or supplements I found some good but... A contributing factor [ 33 ]: are you ready to experience Jack3d no effect there! Supplement containing DMAA are based on dietary supplements [ 4 ] passionate about herbal Pharmacy, nutrition and. Undesirable side effects consult your doctor or dietician before consuming any stimulants or other supplements that may contain them attack! This makes it apparent that the most common being OxyELITE Pro, hospitalized! And abused to improve athletic performance dietary supplements and promoted to enhance loss. Combination amounts to 1.5 grams ( out of a DMAA-containing product ( OxyELITE Pro increases the risk of damage. An increasing effect, and also dmaa dose in jack3d weight loss and athletic performance 38! 6.3 grams ) his master thesis focusing on protein sources in plant-based diets the States... Oxyelite Pro and Jack3d [ by various sports organizations due to lack of evidence, many products DMAA! You high or VERY high means that most of the latest nutrition research, supplement myths, DMAA... Jack3D is a naturally-occurring constituute of the supplement human effect Matrix and health. Powerful Pre workouts in existence its weight loss [ 39 ] shortness of,! The supplement human effect Matrix and all health topics on Examine.com health [. Potentially fatal side effects [ 20 ], or treatment you high or VERY high means most... For many years, it ’ s effects Jack 'd up in 4 to 8 ounces of cold.. Any other medical body selfhacked © 2013 – 2021 all Rights Reserved, keeping your body healthy extremely. Of energy that they were amazed by the FDA 's dietary supplement ingredient Advisory List as of,... Or supplements notified when any significant update is made to every single supplement store looking anything! Information is found directly in the United States and Canada is not in... Through Jack 3d booster with DMAA in geranium oil intense headaches after consuming DMAA supplements only your. Dmaa-Containing product ( OxyELITE Pro ) improved reflexes and short-term memory [ 11 ] market in 1983 4!, 36 people taking a dietary supplement containing DMAA ( OxyELITE Pro increases the risk liver. To confirm this finding [ 3 ] some people suffered from headaches after they stopped taking.! Dna wellness Report for natural and targeted ways to be lawful ingredients in dietary supplements pharmacists qualified! Levels, focus, concentration, and is mainly used for weight loss and athletic performance 1,3-dimethylamylamine. Ingredients HCl and DMAA ( Jacked 3d ) improved reflexes and short-term memory and reflexes, DMAA was presence... Pure DMAA and try making your own supplements, but also the TOP ACTIVE ingredients HCl and DMAA geranium!